Safety Pharmacology
Central nervous system
Cardiovascular system
In Vivo
Blood pressure*, heart rate, influence on the electrocardiogram* under conscious and unrestrained conditions
(Telemetry method: cynomolgus monkeys, rhesus monkeys, beagles, common marmosets)
*: Left ventricular pressure and epicardial electrocardiogram is available in cynomolgus monkeys, rhesus monkeys, and beagles
In Vitro
Effect on the potassium current (hERG current)
(whole-cell patch clamp method: hERG transfected CHO or HEK293 cells)
Respiratory system
Gastrointestinal system
Renal / urinary system