SNBL Japan performs reproductive and developmental toxicity studies and associated studies using rats, mice, rabbits, cynomolgus monkeys, and rhesus monkeys. Most importantly, we are one of only a few facilities in the world with the capabilities to conduct reproductive and developmental toxicity studies using non-human primates. We can perform EFD (embryo-fetal development), PPND (pre- and postnatal development), and ePPND (enhanced PPND) toxicity studies of biotechnology-derived pharmaceuticals.
We have extensive background data, and the Japanese Teratology Society -approved Reproductive and Developmental Toxicologists at SNBL Japan will work to provide an appropriate protocol in reference to the relevant GLP regulations and guidelines. appropriate for your project.
Study Types and Duration
(initiation of study to submission of draft final report)
Effects on fertility and early embryonic development to implantation
Effects on embryo-fetal development
Effects on pre- and postnatal development, including maternal function
(including ePPND studies using cynomolgus monkeys)
We can also perform juvenile toxicity studies and testicular toxicity studies.
Methods of Administration Used in Reproductive and Developmental Toxicity Studies
※ The following examinations can be performed in the dam, offspring, or fetus of cynomolgus monkeys.