Our pathology department quickly provides high-quality histopathological specimens for our clients. We utilize a wealth of background knowledge and experience in toxicologic pathology to deliver accurate diagnoses.
The members of our pathology department include licensed study pathologists, necropsy technicians, and specimen preparation specialists with the following services:
The pathology department constantly strives to offer new services (non-decalcified grind specimen preparation, tissue cross-reactivity (TCR) study, virtual imaging of tissue slides, etc.) to best suit our client's needs.
Our experience in animal dissection is extensive. Our capabilities include but are not limited to dissection of mice, rats, rabbits, dogs, cynomolgus monkeys, pigs, guinea pigs, hamsters, and ferrets. We are especially proficient in the necropsy of cynomolgus monkeys.
Preparation of Pathological Specimens
We prepare specimens from each animal for light microscopic and electron microscopic (transmission, scanning) examinations under the direction of our board-certified pathologists. Please contact us to discuss any special requests for specimen preparation. We like a challenge, which is why we have been able to prepare top class specimens for difficult tissues such as teeth and eyeballs.
Preparation for Light Microscopic Specimens
Preparation for Electron Microscopic Specimens (transmission)
The specimens listed above (prepared for light or electron microscopic specimens) can be archived at our facilities.
Our highly qualified Japanese board-certified pathologists specialize in toxicologic pathology to ensure that you get the best information possible about your compound. Peer review has become more and more important in recent years, and we can recommend third party peer reviewers or support a visit from your in-house pathologist for peer review.
Non-decalcified specimen preparation
We embed hard tissues or samples (bones or teeth after fixation, dental equipment, or medical devices) in resin, and prepare thin sections using grinding and staining.
Tissue Cross-Reactivity (TCR)
TCR studies are recommended as a part of safety evaluation prior to preliminary clinical trials during antibody drug development. We accept and perform TCR studies in confidence, using human tissues, or tissues from various animals including cynomolgus monkeys.
View slides from anywhere in the world
We can easily scan histopathological glass slides and convert them into digital slides for your convenience using the Aperio digital slide system (Aperio AT2, Leica Biosystems). Digital slides can be viewed online anywhere and at any time which can reduce overall cost by omitting the need for specimen transportation.
We collect a variety of animal tissues and store them under humidity and temperature-controlled conditions. Samples are immediately frozen and sent to our clients on dry ice by request. For details, please feel free to contact us.
We provide various animal tissue specimens (HE staining), or corresponding digital slides. Please contact us for more information.