Imaging Modalities



 

In response to the recent growing public concern for animal welfare, there has been an increasing need for imaging devices that allow in vivo, noninvasive, and temporal observations. In addition, many of our imaging devices are also used in clinical settings, so the data using these devices are expected to play an important role as novel biomarkers in clinical trials. Indeed, attempts are already being made to apply this technology to drug discovery from the approaches of both safety and efficacy.

 

In addition to the animal models introduced above, we can also offer flexible support for your projects, from the development of new disease models to pharmacological efficacy evaluations. Please feel free to contact us for more information.

Muscle Mass Measurement by MRI/DXA

 

By measuring muscle cross-sectional area (MRI) and lean mass (DXA), the effect of test article is evaluated in vivo, noninvasively and temporally. Three sites are measured for muscle cross-sectional area: the upper arm, lumber part, and femur (3 slices/ site); and it is possible to separately measure lean mass of the trunk and the limbs. In addition to muscle cross-sectional area, we are also investigating evaluation methods for muscle volume. 

 


3T MRI

  • General MRI imaging of various organs (the brain, liver, and joints) under various enhancement conditions (T1 weighted image, T2 weighted image, Proton Density weighted image, T2*, etc.)
  • Organs and tumor volume measurements
  • Cerebral blood flow, pH measurements, etc.
  • functional MRI measurement of neurological function
  • Evaluation of abnormal sites in the brain ( infarct or tumor)
  • Tumor evaluation using contrast-enhancement MR angiography (delayed enhancement)
  • MR Angiography (vascular visualization by non-contrast method MRI or contrast MRI)
  • Quantitative and temporal evaluation of articular cartilage using a T2 map (currently under investigation)
  • Heart and cardiac function evaluations (currently under investigation)
3T MRI (Allegra, Siemens)
3T MRI (Allegra, Siemens)

4-Slice Helical CT

  • General CT imaging of various organs
  • Measurement of body fat and visceral fat
  • Temporal evaluation of lung impairment
  • Temporal evaluation of skeletal morphology (3D image rendering is also available)
  • Quantitative evaluation of articular cartilage (currently under investigation)
Four-slice Helical CT (Asteion/S4, Toshiba Medical Systems)
Four-slice Helical CT (Asteion/S4, Toshiba Medical Systems)

Angiography System

  • Stent placement confirmation for placement locations
  • Surgery support for brain infarction and myocardial infarction
  • Vessel diameter measurements (angiography)
Diagnostic X-ray angiography system (Infinix Celeve-i INFX-8000C, Toshiba Medical Systems)
Diagnostic X-ray angiography system (Infinix Celeve-i INFX-8000C, Toshiba Medical Systems)
Cynomolgus Cerebral Venous Image
Cynomolgus Cerebral Venous Image
Microcatheter Tip Placement
Microcatheter Tip Placement

X-Ray Equipment

  • Bone density measurements of isolated bones in osteoporosis model of monkeys and rats
  • Body fat, visceral fat, and muscle mass measurements
Dual-energy X-ray absorptiometry device (Discovery-A, Hologic Inc.)
Dual-energy X-ray absorptiometry device (Discovery-A, Hologic Inc.)

pQCT

  • Measurements of bone density (trabecular bone and cortical bone separately) and structural parameters in osteoporosis monkeys
pQCT (XCT-3000, Stratec Medizintechnik)
pQCT (XCT-3000, Stratec Medizintechnik)

X-Ray Fluoroscopy

  • General X -ray imaging
  • Bone length measurement
  • Gastrointestinal motility measurement (measurements of stomach excretion and intestinal transit)
Stationary digital general-purpose X -ray fluoroscopy diagnostic equipment (DREX-WIN64, Toshiba Medical Systems)
Stationary digital general-purpose X -ray fluoroscopy diagnostic equipment (DREX-WIN64, Toshiba Medical Systems)

Optical Coherence Tomography

  • Temporal observations of tomographic images in the posterior eye tissues in general toxicity studies
  • Temporal observations of tomographic images in the posterior eye tissues for ophthalmology -related diseases such as the age-related macular degeneration model (measurement of injury sites at laser-irradiated spots) or the glaucoma model (measurement of the retinal nerve fiber layer)

 

Optical coherence tomography (Spetralis OCT, Heidelberg Engineering)
Optical coherence tomography (Spetralis OCT, Heidelberg Engineering)
Cynomolgus monkey retinal tomogram
Cynomolgus monkey retinal tomogram

Animal X-Ray CT

  • Temporal measurements of bone density in rat and mouse osteoporosis models
  • Body fat and visceral fat measurements in rats and mice
Laboratory animal X-ray CT device (LCT-100, Hitachi-Alloca Medical)
Laboratory animal X-ray CT device (LCT-100, Hitachi-Alloca Medical)
Isolated bones (CT), lumbar vertebrae, tibia, and femur
Isolated bones (CT), lumbar vertebrae, tibia, and femur

In Vivo Imaging System (IVIS)

  • Temporal observations of proliferation of tumors, metastasis, and withdrawal in tumor-bearing models
  • Temporal observations of the biodistribution of cells and proteins (such as antibodies)
  • In vivo imaging is available for whole body for mice and rats, and for head and extremities for monkeys 
In vivo imaging system (IVIS Lumina Series III, Perkin-Elmer Inc.)
In vivo imaging system (IVIS Lumina Series III, Perkin-Elmer Inc.)