General Toxicity
Overview
SNBL Japan offers GLP-compliant single and repeated dose gen tox studies. We conduct studies in both sexually mature and juvenile animals. We can socially house NHPs, canines, and rodents and meet both ILAR and EU Directive 2010/63 size guidelines.
Our patented procedure cages greatly reduce stress on NHPs for examinations as well as standard blood collection and administration under conscious conditions.
Timeline for reporting
Two months for submission of audited draft report after the final necropsy (for a standard 4-week study with 4-week recovery)
Dosing routes
PO (liquid via catheter, tablet, or capsule) IV (bolus injection, and short and long-term infusion, including catheterization), SC, PC, ID, IM
Intraperitoneal, Intranasal, Intraportal
Intragastric/enteral, Intravaginal, Intravesical
Ocular instillation, Intraocular, Eardrops
Intraarticular, Implant (bone, subcutaneous, and intraperitoneal)
Intracerebroventricular, Intracerebral, Subarachnoidal
Epidural, Intradiscal
Please contact us for other dosing route requests.
Special sampling procedures
In addition to the standard blood and tissue sampling, cerebral spinal fluid (CSF) and lymph collection is also possible. We can perform time course-CSF collection after intraspinal dosing by indwelling two separate catheters.
Electrocardiography (ECG) and other vital signs
Holter ECG （Jacketed external telemetry system, JET System) for NHPs and canines
Body temperature, blood pressure, pulse oximetry
Echocardiography for NHPs and canines
