General Toxicity


Overview  

SNBL Japan offers GLP-compliant single and repeated dose gen tox studies. We conduct studies in both sexually mature and juvenile animals. We can socially house NHPs, canines, and rodents and meet both ILAR and EU Directive 2010/63 size guidelines.

Our patented procedure cages greatly reduce stress on NHPs for examinations as well as standard blood collection and administration under conscious conditions.

 

Timeline for reporting

Two months for submission of audited draft report after the final necropsy (for a standard 4-week study with 4-week recovery)

Dosing routes

PO (liquid via catheter, tablet, or capsule) IV (bolus injection, and short and long-term infusion, including catheterization), SC, PC, ID, IM

Intraperitoneal, Intranasal, Intraportal 

Intragastric/enteral, Intravaginal, Intravesical  

Ocular instillation, Intraocular, Eardrops

Intraarticular, Implant (bone, subcutaneous, and intraperitoneal)

Intracerebroventricular, Intracerebral, Subarachnoidal

Epidural, Intradiscal

 

Please contact us for other dosing route requests.

Intradiscal dosing (x-ray photo of the lumbar vertebrae)
Intradiscal dosing (x-ray photo of the lumbar vertebrae)

 

Special sampling procedures

In addition to the standard blood and tissue sampling, cerebral spinal fluid (CSF) and lymph collection is also possible. We can perform time course-CSF collection after intraspinal dosing by indwelling two separate catheters.

 

Electrocardiography (ECG) and other vital signs

Holter ECG (Jacketed external telemetry system, JET System) for NHPs and canines

Body temperature, blood pressure, pulse oximetry

 

Echocardiography for NHPs and canines

CSF sampling via subarachnoid catheter indwelled in the lumbar region or cisterna magna
CSF sampling via subarachnoid catheter indwelled in the lumbar region or cisterna magna