SNBL Japan can test for all parameters listed in the following guidelines for repeated dose toxicity studies.
We can also perform analyses of the parameters listed below.
Please contact us for more details.
Urinalysis
Protein, β2-microglobulin, Albumin, cystatin C, KIM-1, clusterin
These new biomarkers as identified by the FDA or EMEA can be analyzed in accordance with GLP regulations.
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/2008/ucm116911.htm
Coagulation and Fibrinolysis
Platelet aggregation, fibrinogen, fibrin degradation products, D-dimer, TAT, PAI-1, PIC, and bleeding time
Other Blood Components
Whole blood methemoglobin concentration, whole blood calcium ion, hemoglobin A1c, blood gas, and erythrocyte sedimentation rate
Blood Biochemistry
We offer fractional analyses including; lipid fractions, lipoprotein fractions, LDH isoenzyme, ALP isoenzyme, and CPK isoenzyme
Cardiovascular biomarkers
Troponin T, Troponin I, H-FABP, ANP, NTproBNP, and adiponectin
Bone Metabolism Markers
CTX, NTX, TRACP 5b, and P1NP
Bone Marrow
Bone marrow cell count and fractionation analysis
Other Special Examinations
Measurement of liver lipid and glycogen
Hepatic drug-metabolizing enzyme activity (sample preparation and analysis are performed at our Pharmacokinetics and Bioanalysis Center in Wakayama Prefecture )